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KMID : 0613820020120040460
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Journal of Life Science
2002 Volume.12 No. 4 p.460 ~ p.463
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Production and characterization of anti-thyroglobulin monoclonal antibodies
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Nam Kyung-Soo
Shon Yun-Hee
Baek Tae-Seon
Kim Cheorl-Ho
Lim Jong-Kook
Hwang Cher-Won
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Abstract
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Twelve clones of monoclonal antibodies (mAbs) against thyroglobulin were produced and characterized. Among them, three mAbs (TN-1, TN-2 and TN-3) showed high binding affinity to thyroglobulin. From ELISA inhibition assay, TN-2 showed considerable reactivity with soluble thyroglobulin. TN-2 also reacted with phosphatidylserine which has a negative charge in aqueous condition. These results suggest that TN-2 has characteristics of autoantibody concerned with thyroiditis.
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KEYWORD
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Thyroglobulin, autoantigen, autoimmune disease, anti-thyroglobulin monoclonal antibody
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